Regarding the wine64 segfaults reported earlier in the thread, I'm seeing the same thing on -CURRENT with the binary wine-proton packages (both amd64 and i386) and with amd64 wine-proton compiled from ports.
gdb shows that we're crashing in __wine_process_init() in ntdll when attempting to access some TLS item. Only one thread exists at the time of the crash. %gs is not initialized with amd64_set_gsbase(), so we end up trying to dereference 0x30. ntdll's signal_init_thread() isn't getting called, which means that __wine_main() isn't getting called. Indeed, wine_init() is calling __wine_process_init() after loading the ntdll SO.
... and while writing that I see the problem. load_ntdll() is busted if procfs is not mounted. So, if you're seeing wine segfaults, make sure to run
# mount -t procfs none /proc
and update /etc/fstab.