Sorry, but I'm just an enthusiast and a newbie ?
$ truss -H -f env WINEPREFIX=$HOME/.wine-test /opt/steam-utils/bin/lsu-wine-env wine winecfg
1919 101348: munmap(0x623d5000,65536) = 0 (0x0)
1919 101348: freebsd32_mmap(0x1000,0x10f000,0x0,0x5012,0xffffffff,0x0,0x0) = 4096 (0x1000)
1919 101348: freebsd32_mmap(0x0,0x1000,0x0,0x1012,0xffffffff,0x0,0x0) ERR#22 'Invalid argument'
1919 101348: openat(AT_FDCWD,"/usr/home/steamdev/.i386-wine-pkg/usr/local/wine-proton/bin/../lib/wine/ntdll.dll.so",O_RDONLY|O_CLOEXEC|O_VERIFY,00) = 3 (0x3)
1919 101348: freebsd32_fstat(0x3,0xffffc788) = 0 (0x0)
1919 101348: fstatfs(3,{ fstypename=zfs,mntonname=/usr/home,mntfromname=zroot/usr/home,fsid= }) = 0 (0x0)
1919 101348: freebsd32_mmap(0x0,0x1000,0x1,0x40002,0x3,0x0,0x0) = 1648185344 (0x623d5000)
1919 101348: freebsd32_mmap(0x7bc00000,0xcf000,0x0,0x6010,0xffffffff,0x0,0x0) = 2076180480 (0x7bc00000)
1919 101348: freebsd32_mmap(0x7bc00000,0xc2000,0x5,0x60012,0x3,0x0,0x0) = 2076180480 (0x7bc00000)
1919 101348: freebsd32_mmap(0x7bcc2000,0xc000,0x3,0x40012,0x3,0xc1000,0x0) = 2076975104 (0x7bcc2000)
1919 101348: freebsd32_mmap(0x7bcce000,0x1000,0x3,0x1012,0xffffffff,0x0,0x0) = 2077024256 (0x7bcce000)
1919 101348: munmap(0x623d5000,4096) = 0 (0x0)
1919 101348: close(3) = 0 (0x0)
1919 101348: openat(AT_FDCWD,"/home/steamdev/.i386-wine-pkg/usr/local/wine-proton/lib/wine/libm.so.5",O_RDONLY|O_CLOEXEC|O_VERIFY,00) ERR#2 'No such file or directory'
1919 101348: openat(AT_FDCWD,"/usr/local/lib32/libm.so.5",O_RDONLY|O_CLOEXEC|O_VERIFY,00) ERR#2 'No such file or directory'
1919 101348: openat(AT_FDCWD,"/home/steamdev/.i386-wine-pkg/usr/local/lib/libm.so.5",O_RDONLY|O_CLOEXEC|O_VERIFY,00) ERR#2 'No such file or directory'
1919 101348: openat(AT_FDCWD,"/usr/local/lib/gcc9/libm.so.5",O_RDONLY|O_CLOEXEC|O_VERIFY,00) ERR#2 'No such file or directory'
1919 101348: openat(AT_FDCWD,"/usr/lib32/libm.so.5",O_RDONLY|O_CLOEXEC|O_VERIFY,00) = 3 (0x3)
1919 101348: freebsd32_fstat(0x3,0xffffc788) = 0 (0x0)
1919 101348: fstatfs(3,{ fstypename=zfs,mntonname=/,mntfromname=zroot/ROOT/default,fsid= }) = 0 (0x0)
1919 101348: freebsd32_mmap(0x0,0x1000,0x1,0x40002,0x3,0x0,0x0) = 1648185344 (0x623d5000)
1919 101348: freebsd32_mmap(0x0,0x35000,0x0,0x2000,0xffffffff,0x0,0x0) = 1650458624 (0x62600000)
1919 101348: freebsd32_mmap(0x62600000,0xf000,0x1,0x60012,0x3,0x0,0x0) = 1650458624 (0x62600000)
1919 101348: freebsd32_mmap(0x6260f000,0x24000,0x5,0x60012,0x3,0xe000,0x0) = 1650520064 (0x6260f000)
1919 101348: freebsd32_mmap(0x62633000,0x1000,0x3,0x40012,0x3,0x31000,0x0) = 1650667520 (0x62633000)
1919 101348: freebsd32_mmap(0x62634000,0x1000,0x3,0x40012,0x3,0x31000,0x0) = 1650671616 (0x62634000)
1919 101348: munmap(0x623d5000,4096) = 0 (0x0)
1919 101348: close(3) = 0 (0x0)
1919 101348: freebsd32_mprotect(0x7bc00000,0xc2000,0x7) = 0 (0x0)
1919 101348: freebsd32_mprotect(0x7bc00000,0xc2000,0x5) = 0 (0x0)
1919 101348: freebsd32_mprotect(0x62633000,0x1000,0x1) = 0 (0x0)
1919 101348: SIGNAL 11 (SIGSEGV) code=SEGV_MAPERR trapno=12 addr=0x18
1919 101348: process killed, signal = 11