You could sharpen images, but once you do, it's no longer the same image. It's a recreation of that original image. It depends on if you want the original, then you'll have to stick with the original blurry image. If you use a program with an algorithm or ai, it's a recreation. ImageMagick is the one I know of.
For me, if it's for entertainment, then upsampling is perfect. Taking a 16bit audio, and upsampling it to 24bit will create artificial parts to the music, which may vary slightly on each pass, which aren't the original. If it's for presentation, upsampling is fine. If it's for documentation or showing results, I'll stick with the blurry image.