I used a dual-bay USB-C external HDD station for over a year no problem as a NAS with a laptop NTFS, ext4, ZFS, and briefly UFS. I'd use RAID1 with software raid or as-natively as ZFS can do it! I normally do single-drive and occasionally connect a 2nd disk for backup sync.
There's hdparm commands to disable HDD suspend/power-saving stuff at the firmware level (I set stuff years ago from Linux and it carried-over to Windows and FreeBSD)l; I had no problem with quick access from Linux and FreeBSD, but wasn't a fan of Windows having to spin-up first and delay GUI access (efficient but annoying

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I've done daily reboots most of that year no problem and had a few random power-offs no data loss or issue. Even had it fly off a table with a WD drive and still working months later
The idea with a second HDD and occasionally syncing is actually also not that bad eventually, because if the second HDD is not used, it would probably sustain longer, and if the first HDD breaks, the second one could be used until the first one gets replaced.
I am just wondering if I use one HDD or RAID with both HDDs and mount it/them on each boot to a directory then that would mean that they should actually not suspend, right ?
Especially NAS HDDs which should work 24/7.
Suspending means that on each wake up they need to spin up again which probably wouldn't be very good if happening frequently.
My typical use case is that I need a HDD to be available each boot as I frequently copy data over from HDD to RAM.
So, I am actually wondering which approach would be better.
1 HDD for continuous usage, and one for backing stuff up + an external backup on a external HDD ?
Or should I directly use 2 HDDs in a RAID 1 construct + keeping an external backup ?
Obviously if a HDD stores data, and doesn't spin up/down as often it should live longer, if I am not wrong.
Would be interesting to know which of the methods is actually the preferred one.
Space is not an issue as both have 12 TB.
As others have suggested, a drive with 2232 power on hours is not expected to fail mysteriously (even if it has been power cycled often). A second drive doing the same thing is not likely to be a coincidence. Two drive failures point to something in the environment. You need a plan to test the components one at a time.
I believe it is the motherboard, because I changed that some time ago, and then problems started with the HDDs.
Just to make sure I want to get a external 2-bay dock station and see whether those problems would return.
I checked SATA cables, too, but they acknowledge new drives, and I even tried new SATA cables on different connections, but same result.
Another part could be the PSU, but that is very unlikely, because if it would be faulted, I would have way more problems than just the HDDs.