Now knowing that it was LTO, and it only appears to hang, I will try building all of chromium, thunderbird and firefox, all with LTO enabled, and all in parallel within synth. I have disabled the timeout in synth and will go out and not watch it.
Before starting synth, the machine was running with xfce and various programs, and the load average was 0.25.
10:30AM up 6 days, 13:48, 1 user, load averages: 0.25, 0.51, 1.17
In a terminal window synth force www/firefox www/chromium mail/thunderbird
After ten minutes
10:41AM up 6 days, 13:59, 1 user, load averages: 125.14, 85.96, 64.00
Having gone out for a couple of hours, when I came back, it was complete with all three built successfully.
From the log files and can see that thunderbird took about 35 minutes, chromium about 100 and firefox less than 90 minutes - peculiarly, faster than when I built it on its own with LTO. I did not watch to see if any appeared to hang.