I'm also thinking now about these performance implications. Theoretically the OS partition will very rarely be accessed, mainly for writing logs I guess but it's indeed an unknown.
I'm assuming that there is little to no user login on this, it's basically big honking data server that is accessed remotely, so agree that the OS portion should be relatively quiet.
The 3-way mirror was based more on the conversation around "backing up" and using dd. This thread to me takes that out of the equation.
Right now it seems like your requirements are "remotely accessed 400TB with lots of small files, need as much performance as possible, desire to have redundant boot devices".
Is that a fair summary?
If so I'd look at the system 2 different parts:
Booting/OS
Performance data
Boot devices, mirror is good, but one could also install on a USB and then duplicate that so if the device fails, you plug another one in. Your "I don't want to have any troubles", well can't guarantee that can we. I look at this as "get back in service as quickly as possible".
Assuming this machine has gobs of memory, what about boot from USB but into a memory image (Linux initramfs idea) and basically run the OS from a RAM disk? That takes the USB out of the picture except for the booting, so in theory keep it safe longer?
The Data Pool. I think dedicating physical devices to the "special" and not trying to split them into OS and special is better in the long run. If you do have physical room to make the special into a 3-way mirror (even with an adaptor) I think that would be better. Just keep in mind that (this is a generalization) that writes to a mirror device roughly complete at the slowest, reads at the fastest, so keep them the same or close in specs.
I've never done this type of thing so have not hands on experience, but yes read a lot and have followed interesting discussions about it, so take everything I write as opinion/with a grain of salt.