I've only ran a Windows 10 guest at this point. Seems to work fine, though it is a little slow. That may be the RDP connection, but I know there are some performance enhancements coming in 13 and if I can switch the IO driver, it is supposed to be faster. My main motivation is to run MS Office, as some of the formatting I have to do for classes is very difficult to perform in Libre/Open Office. For that purpose, it is working well enough.