Assuming that the two 4TB drives are in a mirror and the 5TB drive is its own distinct vdev, then if that 5TB drive fails you would lose everything. Single-disk vdevs are always a bad idea.
The reason is that ZFS tries to spread data and metadata evenly across all devices, including metadata about the pool itself. If a non-redundant virtual device dies, you lose both the files stored on that virtual device and some metadata about the pool itself. The pool can't properly function or be reconstructed without all that metadata intact, so you'd lose everything else in the pool as well.