please how can I block p2p

You might want to give us a little more information. Mainly on how your network is setup.

Short and quick solution? Block all direct internet access from your workstations. If they need web access, configure a proxy and force everything through it.
 
I am configuring a squid proxy, I want to do is to block p2p and squid with the natd not closing all the ports, you can block with the squid?
 
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