HTTP Request Smuggling/Splitting

Use light weight web server such as nginx or lighttpd if possible.

If you need Apache, put it behind light weight server.

Use jails to split up php, apache and other services

Use chroot() provided by lighttpd or mod_chroot for Apache, which lock down server inside jail.

Run freebsd securelevel 3

Limit connection per ip using server config or firewall settings

Tune TCP stack

See the following thread:
http://forums.freebsd.org/showthread.php?t=4108
 
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