Given that no current miner software supports GPU mining any more and CPU mining is a futile undertaking, the answer is very likely: yes, without access to expensive, high-hashrate ASIC hardware you will probably spend more money on the custom rig and power costs than you will ever make in return. Even with sophisticated hardware capable of 14 TH/s and above, considering all costs involved, you will need about a year to break even. If you're in it for the profit, you're better off buying and selling Bitcoin, etc. on a speculative basis than trying to mine your own.