According to some information on the mailing lists, there appears to be an issue with drm-kmod package being built against 12.0 and not working with 12.1, requiring it to be built from ports. There would not be much need to set options, but if you had not installed anything by ports before, all the build packages would prompt for configuration options. It isn't a huge issue, but quite an annoyance.If you're going with the defaults for everything why don't you save yourself a lot of time and just use the packages?
You can, temporarily, switch to the release_1 repository, that's specifically for 12.1. The only 'downside' of release_1 is that it's based on latest, there's no quarterly branch for it.According to some information on the mailing lists, there appears to be an issue with drm-kmod package being built against 12.0 and not working with 12.1, requiring it to be built from ports.