For my local tmux I have the backtick set as the Prefix key. F11 to add a new window, F12 to step between windows. I just find that easier/quicker. Which is handy for when I ssh into hashbang.sh ... that also runs tmux using the standard keys (ctrl-b prefix) ... as the two don't collide. I have my tmux menubar at the top of screen, hashbangs is the default bottom of screen. No need for multiple monitors and I don't use panes (split a single tmux window down and zoom in/out one of many panes), but instead just flip between windows (each program maximised).
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hashbang.sh like many provides email, irc, textual browser. Local has calcurse (calendar/todo/diary), cmus (music) ..etc. and I like mc for file manager and text editor. I could get by with that alone, however for https/browsing X/gui is pretty much a necessity. My android phone however could be used as a alternative to that so fundamentally could I live a day without firefox/X/gui and use just my phone instead .. yes easily, but for actual work, cutting and pasting from a browser into a text file etc. would be inconvenient. Whilst I can mount my phone so that its folders appear as any other folder on my desktop system, its more awkward. If I could mount my phone and have the desktop keyboard/mouse control it, and have its screen displayed on another monitor (or window) then that would be more viable. A gap in the market however is that such a 'app' isn't readily available AFAIK (my awareness on that front however is lacking, so hopefully someone might pipe in with a pointer to such a app
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A nice feature of using a ssh server is that you can just detach (ctrl-b d) and then later login again and attach ($ tmux attach) back into the exact same (still running) session with all your windows ready to go.