Best ZFS setup

I've just installed on a 250GB drive using 20GB for the OS (on UFS) and am unsure of the best ZFS setup for the rest of the system.

The pc also has a 640GB and a 1TB drive installed.

Is it wise to make a zpool out of all available space, ie, ad4s2, 640GB + 1TB. This is the bit I'm unsure about this as it's including a partition.
If I should only use whole disks, what is best to do for ad4s2? a seperate zpool or is it better to format it as UFS.
 
Thanks for the links. I decided to go with max security for the moment, might dabble with multiple disk pool(s) + mirrored setup when I have some free cash.
 
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